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Regarding the SEV group, B12-upregulated genes had GO annotations related to cytoplasmic translation (tRNA and rRNA processing), adaptive immune response, ncRNA processing, miRNA-mediated gene silencing, proteasome-mediated ubiquitin-dependent protein catabolic process, cobalamin transport, and negative regulation of transcription by RNA polymerase II ( Figure S3 )
Chest 129 , 15231530 (2006)
Cyanocobalamin remains stable in solution longer than methylcobalamin, simplifying storage and extending shelf life
However, subsequent analysis showed that 500mcg produced nearly identical results to 1mg in body composition changes
