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In line with the potential of ABC transporters to efflux anticancer agents, their overexpression has been associated with poor response to chemotherapy and multidrug resistance (MDR) 27

Proc Natl Acad Sci USA 89 : 1019310197

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Another preclinical rat GBM model study also reported no additional effect when treated with ITPP (156)

5.3 Plasmid-mediated AmpC- -lactamase In E