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The involvement of OCTN1 in cancer metabolism, is probably unrelated to the poor ability of this transporter to mediate carnitine transport, however, it is interesting to know that OCTN1 is involved in the uptake of anti-cancer drugs (Table 1) such as Cytarabine (Zheng et al., 2016), mitoxantrone and doxorubicin (Okabe et al., 2008)

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The flexible loop is expected to be stabilized in vivo by adopting a closed structure binding the substrate aldimine, whereas the apoenzyme does not bind the substrate, leading to its preferential proteolysis (Matsuda et al., 2004)

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Therefore, future studies must focus on the proper design to diminish the possible sources of bias

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