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The synergistic effect of probiotics and prebiotics can decrease the intestinal lumens pH and stimulate cell proliferation (Wichmann et al., 2013)

These agents function by mimicking the actions of endogenous GLP-1, binding to its receptor to enhance glucose-dependent insulin secretion from pancreatic -cells while suppressing glucagon release from -cells

Administration: Injections are subcutaneously applied into the abdomen, thighs, or arms

reported that berberine alleviated renal injury by attenuating Toll-like receptor 4 (TLR4)-dependent NF-B-mediated inflammation (Zhu et al., 2018)

Enhancing selectivity involves developing high-specificity ligands and leveraging E3 ligases that are highly expressed in specific tissues or tumors [337, 338]