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Whereas XpdTTD/TTD mice generally show less exploratory behavior compared to wild-type littermates, FOXO4-DRI-treated animals were noticeably more active. we scored the responsiveness of the mice to gentle physical stimuli

doi: 10.1016/j.yexcr.2013.05.001 179 OjelabiOALloydKPDe ZutterJKCarruthersA

In the presence of deoxyadenosine triphosphate (dATP) and adenosine triphosphate (ATP), Cyt-C is released from mitochondria and bound to Apaf-1 to form a poly-complex, which in turn activated the caspase cascade and thus induced apoptosis [72]

Cysteine is instead the precursor of glutathione

Stability, consistency and replicability We evaluated the stability of MetSiM construction by testing two key parameters: the contribution of individual metabolites and the K pert values