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Gene level quantification was performed using HTSeq-counts v.0.6.0 based on the GRCm38.90 genome annotations

Having an MTHFR variant means you make less methylfolate naturally, so direct supplementation makes sense

Furthermore, extracellular lactate must enter cells through MCTs before contributing to lactylation reactions, which have been demonstrated to modulate ferroptosis through multiple mechanisms (51)

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Mancini A, De Marinis L, Calabr F, Sciuto R, Oradei A, Lippa S, Sandric S, Littarru GP, Barbarino A J Endocrinol Invest
