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If you stop suddenly: You might notice rebound dullness or breakouts (especially if skin was already sensitive) Oxidative stress can spike temporarily, especially if theres no antioxidant support from diet or skincare If you taper: Your body has a chance to adjust its GSH homeostasis more gently You can monitor changes and compensate with diet, skincare, or other supplements A lot of U.S.-based functional medicine docs recommend a cycling approach on for 3 months, off for 1

Novel approaches utilising red-shifted dyes to reduce autofluorescence and to allow multiplexing of samples are also emerging

Biochem J (2016) 473(13):184557

-Hydroxybutyrate: A signaling metabolite in starvation response