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Y., Vance V., Hommel J

Individuals with a history of thromboembolic disorders should also be carefully evaluated prior to treatment, especially when HCG is used as part of ovulation induction protocols in women, as it may increase thrombotic risk through hormone elevation

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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes