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doi: 10.1242/jcs.187260 92 QuikM

Key mechanistic insights into TCM efficacy are summarized, focusing on the repair of the intestinal mucosal barrier, modulation of bile acid metabolism and gut microbiota composition, and enhancement of intestinal immune barrier function

The goal of this project was to chemically modify this tripeptide in such a way to enhance its metabolic stability and barrier permeability to produce a drug candidate with potential clinical utility

[4, 5] IAP is expressed and secreted by intestinal epithelial cells and remains active within the mucosal membrane as well as the intestinal lumen

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