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DES is also linked to hypermethylation of the Hoxa10 genes promoter and intron regions, which leads to anterior reproductive tract alterations (Falck and Forsberg, 1996

Copper is also capable of causing DNA strand breaks and the oxidation of bases via oxygen-derived free radicals [69]

Acta Paediatr (1994) 83(2):18891.10.1111/j.1651-2227.1994.tb13048.x 87 ButteNFGoldblumRMFehlLMLoftinKSmithEOGarzaCet alDaily ingestion of immunologic components in human milk during the first four months of life

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In clinical practice, individualized drug regimens need to be developed based on patient-specific conditions, and therapeutic drug monitoring and individualized genetic testing are effective tools to increase the efficacy and decrease the adverse effects of metformin for PCOS therapy