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Possible process of compromised immunotolerance in women is asymmetrical X chromosome inactivation (XCI), which cause evade from the presentation of X-linked self-antigens in the thymus and following deterioration of T cell tolerance

This patient's diffuse encephalopathy, extreme hyperthermia, and profound autonomic instability indicate a systemic toxic-metabolic process rather than a focal structural brain lesion

doi: 10.1111/j.1574-6968.2007.00760.x