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Description
Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

Anandakrishnan, R., Aguilar, B

Why 4 week intervals matter The 4 week escalation interval was not chosen randomly
Both tirzepatide and semaglutide share a similar profile of side effects, which are mostly gastrointestinal in nature

In clinical trials, 6-16% of participants discontinued retatrutide due to gastrointestinal adverse events (Jastreboff et al., NEJM, 2023)
