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Of note, in this study protocol, vitamin C was administered on three days of every cycle and was discontinued after six months, which might not be enough to induce the anti-cancer effects of vitamin C

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however, IPC has been studied as a potential therapeutic strategy to mitigate tissue damage associated with IRI (140145)

These findings indicate that GPX3 is essential for the clonal survival of OCSCs (96,97)

Furthermore, ferroptosis can be inhibited by glutathione (a water-soluble antioxidant) or -tocopherol (a lipid-soluble antioxidant), indicating that ferroptosis is not solely dependent on iron but is also closely associated with oxidative stress (112)