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Prospective study of 30 patients treated with vitamin D, magnesium, and vitamin B12, and 25 control patients, showing shorter hospitalization and lower oxygen and ICU requirements with treatment

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Mechanical hyperalgesia may also be caused by centrally amplifying responses

-More rarely, tinnitus, insomnia, irritability or seizures may occur
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