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doi: 10.1093/fampra/cmi021

On the other hand, the allelic distribution of KRAS mutations varies significantly among cancer types, reflecting different underlying mutational processes (for example, KRAS G12C association with smoking) and suggesting tissue-specific oncogenic signaling that varies among KRAS alleles, carrying differential sensitivity to targeted therapies [172,173]

These include Werner syndrome, for whom the life expectancy is 47 years
Some studies have found that circ FOXP1 was significantly overexpressed in the serum of NSCLC patients [159], and the down-regulation of circ FOXP1 can inhibit the proliferation of lung cancer cells [160, 161]
