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It is worth noticing that the interpretation of these findings is complicated by the difficulty of extricating the pharmacological effects of drugs from the response to conditioned stimuli paired with drug administration or self-administration

The authors found that nuclear factor erythroid-2-related factor 2 (NRF2) as a main transcription factor in response to oxidative stress was significantly induced and bound to the promoter of NPC1L1, therefore transcriptionally contributing to NPC1L1 expression

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Floh, L., Toppo, S., Cozza, G

Symptoms of deficiency can vary from person to person, but may include impaired brain function, tiredness and lack of energy, breathlessness and fatigue, headaches, pale skin, heart palpitations, loss of appetite and weight loss, anxiety and depression