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Furthermore, analysis of immune cells in the mice demonstrated that a marked reduction in the expression levels of pro-inflammatory receptors (CD68 and CD80), pro-inflammatory cytokines (TNF- and IL-6), and MMPs (MMP-3), further confirming the therapeutic efficacy of BBR-loaded PEVs

Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, et al

[75] For several decades, the vitamin Kdeficient chick model was the only method of quantifying vitamin K in various foods: the chicks were made vitamin Kdeficient and subsequently fed with known amounts of vitamin Kcontaining food

Of course, it is unwise to directly compare the doses given to animals and the doses given to humans, as the bodys surface area should also be taken into account when translating doses between species

Unlike conventional pharmacological agents, BPC-157 appears in experimental models as a multifunctional regulator of cellular signaling