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Description
Kynurenine pathway dysregulation has been implicated in neurological disorders, including Huntingtons, Alzheimers, and Parkinsons disease, multiple sclerosis, and epilepsy (Vecsei et al., 2013) as well as in neurodegeneration caused by acute insults, such as ischemia and excitotoxicity (Stone et al., 2012)
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No clear phenotype has been associated with CAV2 deficiency in humans, while Cav2 knockout mice demonstrate severe pulmonary dysfunction along with little or no change in caveolin-1 expression and caveolae formation [46]
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[DOI] [PubMed] [Google Scholar] 96.Wang S, Feng Y, Han X, Cai X, Yang L, Liu C, et al
