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The annual number of publications increased from 352 in 2014 to 751 in 2022, as shown in Figure 2

Yousefi B, Mohammadlou M, Abdollahi M, Salek Farrokhi A, Karbalaei M, Keikha M, et al

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They can bind G-protein-coupled estrogen receptor 1 (GPR30), with effects driven by both genomic and non-genomic regulation involving different cellular signalling pathways, such as intracellular increase of calcium or NO levels (Reference Ropero, Alonso-Magdalena and Ripoll75) , as observed in human endothelial cells after stimulation with equol 100 nM (Reference Rowlands, Chapple and Siow76)

Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies
