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Sies H, Jones DP

HK-I is the predominant HK isozyme in tissues that depend strongly on glucose for their physiologic functioning, such as brain, muscle, and erythrocytes

doi:10.1186/s12931-018-0761-8 Myllyla M, Hammais A, Stepanov M, Anttalainen U, Saaresranta T, Laitinen T

These findings were reported in earlier studies showing that rotenone induced neural degeneration with shrunken neurons and pyknotic nuclei in rats [102]

Besides exercise and nutrition, the paper also highlights weight loss, caloric restriction, and metabolic flexibility as key strategies to reduce oxidative load and improve glutathione recycling