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Briefly, the nanoSIMS images and the fluorescence images were overlayed, and circular ROIs (1.2 m diameter) were selected in TNR or calreticulin-rich areas, or within cell nuclei, based on the fluorescence images

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By applying transcriptome sequencing to determine the possible pharmaceutical target of N-methyl-N-nitrosourea (MNU)-induced mouse models, researchers ascertained that ubiquitination and degradation of GPX4, catalyzed by Cullin-7, resulted in PR ferroptosis (112)

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