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This underlies the relevance of hyaluronan degradation and this enzyme system in regulating endothelial glycocalyx function and diabetic vascular complications (64, 223)

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The loss of these cells can further exacerbate the intestinal barrier dysfunction, creating a vicious cycle that may contribute to the overall pathology observed in SLE patients ( In SLE patients, the gut microenvironment can experience a heightened level of inflammation brought about by the autoimmune nature of the disease