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A redox shift is a change in the bioenergetic supply of electrons, leading to changes in the intracellular ratio of NAD + /NADH as redox currency, oxidized glutathione over GSH (GSSG/GSH) as redox buffer, and plasma cystine/cysteine (cySS/cys) as systemic buffer
Indeed, by targeting these unique features in these cancer cells, we recently showed that high dose vitamin C could selectively kill KRAS or BRAF mutant CRC cells
These results were invalidated by the comparative testing of Gpx to GR in mice liver models