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Despite the initiation of clinical trials across various programs and the endorsement of numerous phase 2 and 3 trials, 261,262,263,264,265 the presence of side effects or toxicity remains indeterminate, necessitating prolonged drug usage and further pertinent data

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With the exception of quantitative measures such as distance walked in 6 min, the methods are highly subjective and a source of bias due to their subjectivity

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