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eLife 10:e64891
Stohr T, Krause E, Selve N
Ficlatuzumab (AV-299) is a humanized, high-affinity monoclonal antibody that can block HGF/c-Met binding and mediate downstream phosphorylation of the signaling pathway (Tabernero et al., 2014)
These are called glutathione peroxidase 7 and 8 (Gpx7 and Gpx8), which have been shown to drive the oxidation of PDI in vitro (Nguyen et al
Mutations in the insulin/insulin-like growth factor receptor gene, daf-2 , induce daf-16- mediated transcription of many cytoprotective and antiaging genes 39,40,41
