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Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-/Smad2/3-mediated epithelial-mesenchymal transition
[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Wink L.K., Adams R., Wang Z., Klaunig J.E., Plawecki M.H., Posey D.J., McDpugle C.J., Erickson C.A
In glioblastoma, galangin suppresses cell proliferation by inducing pyroptosis through the upregulation of GSDME expression, with no effect on GSDMD expression (Kong et al., 2019)
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Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X
