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The issue is the absence of the infrastructure needed to use them safely: No approved baseline laboratory testing No interval monitoring No adverse event tracking No way to verify what is actually in the vial For patients, this matters enormously

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For example, mitophagy mediated MQC heavily depends on efficient lysosome degradation, whose dysregulation reversely suppresses mitochondrial function, so they all interplay by each other to form a vicious cycle, participating in the pathogenesis of neurodegenerative diseases