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Simultaneously, inhibition of GDH limits the reversible interconversion between glutamate and -ketoglutarate, exacerbating the deficit

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Next, cells were washed in Perm/Wash buffer, resuspended in staining buffer and analyzed with BD FACSCantoII (BD Biosciences) and HTS sampler

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AngII stimulation enhanced the invasion and migration of AGTR1-overexpressing T24 cells, but did not promote their proliferation, suggesting that ERK-driven proliferative signaling may have been counteracted by the downregulation of Akt activity