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Two mutations isolated from independently injected embryos were identified by PCR amplification of the region surrounding exon 2 of the D2hgdh locus using oligos 5-TCCTCCACGATGAGATTCCAAC -3 and 5-TGATCGAAGTTCTCCAGGATGC -3
Treatments that could address redox metabolism abnormalities include methylcobalamin with and without folinic acid in open-label studies and vitamin C and N -acetyl-l-cysteine in DBPC studies
The use of substances to enhance some aspect of an individuals physical or emotional state is not a new phenomenon
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