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Preparation of HBV from HepAD38 cells and infection with HepG2-hNTCP cells HepAD38 cells were cultured for three days in DMEM/F-12 medium (Gibco, 11320033) supplemented with 10% heat-inactivated FBS, 100 U/ml penicillin, and 100 mg/ml streptomycin in an incubator at 37 C

reported that the copper (II) complex of salicylate phenanthroline [Cu(sal)(phen)] can significantly increase the ROS levels in HCC cells and promote apoptosis (157)

These epidrugs have been tested for various cancers and several clinical trials have been performed on patients with solid tumors (Yoo et al., 2004)

M.MartyM.BrienzaS.MissetJ

The initial manuscript was written by RT, JP, MR, and HN