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[5] However, because it is not FDA-approved for therapeutic use in the United States, its administration is considered off-label or investigational, making medical supervision essential rather than optional

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Understanding these differences helps researchers select the appropriate compound for their specific laboratory protocols

Experimental data showed that 10 M resveratrol completely inhibited the release of the inflammatory mediator IL-6, while resveratrol-3-sulfate and resveratrol-disulfate decreased by 84.2 29.4% and 52.3 39.5%, respectively, and the release of TNF- was reduced by 48.1 15.4%, 33.0 10.0%, and 46.7 8.7%, respectively, in macrophage assays in vitro 60

strongly evidence based but weakly reflected in practice