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This genetic metabolic block severely impairs the body's ability to produce cellular energy and clear out neurotoxins, directly contributing to the hallmark symptoms of ME/CFS, including profound post-exertional malaise (PEM) and unrefreshing sleep

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[ 78 , 79 , 80 ] Nevertheless, additional investigation is required to comprehend the mechanisms through which BACH1 expression is induced, including low oxygen induction, oxidative stressinduced inflammatory factors, hormones and cytokines, and other potential pathways

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No human clinical trials exist for BPC-157 in GERD or any other indication

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