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[DOI] [PubMed] [Google Scholar] 25.Thornburg LP, Rottinghaus G, Dennis G

doi: 10.1186/1471-230X-12-115 118 HuangTLiuYZhangC

doi: 10.3322/caac.21398 156 WardillHRde MooijCEMda Silva FerreiraARvan de PeppelIPHavingaRHarmsenHJMet al

It is a ubiquitous enzyme that catalyzes the NADPH dependent reduction reaction of oxidized glutathione (GSSG) to reduced glutathione (GSH)

A nonexclusive alternative explanation for the kinetic patterns with HEDS (and the decreased enzyme activity at high GSH concentrations) could be a Grx(SSCH 2 CH 2 OH) intermediate that is attacked by GSH according to monothiol mechanism (i) from Fig