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Numerous reviews and research articles mention analytical details, protocol variations and innovations like changing the reaction monitoring from 515 to 580 nm in order to minimise interferences due to carotenoids [94], separation from radicals of the compounds tested in order to avoid spectral overlap by means of HPLC-PDA detectors [95] or HPLC postcolumn configuration that allows the estimation of the total antioxidant activity of the individual compounds in a mixture [96,97]

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The early increase in iron observed in the cortex of PSAPP mice begins at 24 weeks of age, whereas hippocampal iron content rises from 13 to 24 weeks of age, followed by a subsequent decline in hippocampal iron levels between 24 and 56 weeks of age (Li D

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