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Research published in Gastroenterology demonstrated that nanomolar concentrations of KPV inhibit NF-kB and MAP kinase inflammatory signaling pathways through PepT1-mediated transport, and reduce pro-inflammatory cytokine secretion

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[145] Animal studies with this compound showed it to be free of hallucinogenic effects at doses up to 30 mg/kg, although several of its more lipophilic analogues did produce the head-twitch response known to be characteristic of hallucinogenic effects in rodents

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Below is a table comparing key characteristics of trazodone and narcotic substances to clarify their differences and help readers understand their distinct roles in treatment