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6 Pharmacologic management may be considered in patients with severe gynecomastia of recent onset (less than 6 months), those with persistent gynecomastia after discontinuation of offending medications or substances, and those in whom an underlying cause has not been identified

Subsequently, monoclonal proliferation and secretion of IFN- promote M1 activation

This is based on the role of SAM as both an allosteric activator of cystathionine -synthase and an allosteric inhibitor of MTHFR, the enzyme that produces 5-methyltetrahydrofolate (Figure 2)

Maldonado, E., Urbina, F., & Solari, A

Compared with surgery, chemotherapy, and other anticancer means, PDT has multiple advantages such as non-invasiveness, negligible drug resistance, and spatial selectivity