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Significantly, SSB is an IDP that forms a condensate (Kozlov and Lohman, 2024) whilst DnaA also contains an intrinsically disordered region (Hou et al., 2022)

-glutamyl-transferase is a membrane-bound enzyme in the liver and cells lining the bile ductules and bile canaliculi

The selected dosages of fucoidan were based on the findings of earlier studies (Sony et al., 2019

Some of the more promising include anakinra, rilonacept, canakinumab, BCX4208 and arhalofenate

As an example, it has been demonstrated that a mutation (S662G) in PER2, which is known to be responsible for the familial advanced sleep phase syndrome, increased resistance to apoptosis and E1A- and RAS-driven oncogenic transformation, as well as affected tumorigenesis in p53 R172H/+ mice, with a cancer-sensitized genetic background 38