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2 University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA, 3 University of Puerto Rico School of Medicine, San Juan, Puerto Rico

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GDF11 and geronic effects In prior publications [12,14,15,78] , we reported that supplementation of circulating GDF11 can reverse age-related deficits in multiple major organ systems, recapitulating many of the effects seen with heterochronic parabiosis