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Description
Functions of Ether Lipids Membranes: Within a membrane, the acyl chain in plasmalogens is oriented perpendicularly to the membrane surface in marked contrast to the sn 2 acyl chain of diacyl glycerophospholipids where there is a bent conformation, while the head-group lacks a carbonyl oxygen in the sn -1 position and is much more lipophilic

Endocr Metab Immune Disord Drug Targets (2021) 21(10):184568
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Conversely a decrease in cellular cholesterol levels will increase SREBP2 expression resulting in an increase in LDL receptor activity and an increase in miR-33, which will result in a decrease in LXR activity, decreased expression of ABCA1 and ABCG1, and a reduction in cholesterol efflux
