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Hence, some traditional physicians recommend routine treatment by the enema, a procedure involving the infusion of water or other fluids into the colon through the anus, in order to shorten the contact time of the toxins in the colon [4, 5]

[107] reported that decreased expression of Bmal1 could inhibit endothelial cell activities, including proliferation, migration, and vascular network formation, by downregulating VEGF expression

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Neither compound raises major red flags on its own, and the combo doesn't seem to introduce new concerns