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doi: 10.1038/s41419-025-07497-0
The ligand occupies the ATP binding site of c-Met, competes with ATP by forming hydrogen bonds with Met 1160, and binds with Asp 1222 in the active region of c-Met to form hydrogen bonds, thus producing strong kinase inhibitory activity (Fig
Almost 10,000 events were collected for each sample and analysed by flow cytometry (Beckman Coulter, Epics XL)
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