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[PubMed: 17720994] 104

doi: 10.1111/imr.12752 64 BachelerieFBen-BaruchABurkhardtAMCombadiereCFarberJMGrahamGJet al

These reactions are under the control of several biotransformation enzymes which are sensitive to factors such as cofactor and conjugation substrate depletion and the inhibition (and sometimes the upregulation) of specific enzymes in the system

Further information from the literature, CRISPR-Cas studies 32,33,34 , and the availability of suitable inhibitors were additionally used to identify candidate targets suitable for experimental testing

10.1038/s41584-018-0109-2 13 CrossM.SmithE.HoyD.CarmonaL.WolfeF.VosT.et al (2014)
