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Vitamin E helps protect brain cells from oxidative stress
doi: 10.1074/jbc.RA118.002721 124 SongTZhangYZhuLZhangYSongJ
Moreover, O-GlcNAcylation of Bmal1 in hippocampal neurons of diabetic mice has been demonstrated to enhance its interaction with Clock, resulting in dysregulated circadian clock gene expression

P.HillK.SandersK.et al (2006)

As we age, our natural NAD+ levels decline significantly, contributing to fatigue, cognitive fog, metabolic slowdown, and accelerated aging at the cellular level
