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Furthermore, the knockdown of TGFb-associated genes abolished the adverse effects evoked by TGFb ligands

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Malignant cells release factors like TGF- to transform normal fibroblasts into CAFs, which then secrete signals such as HGF and CXCL12 that further support cancer cell proliferation and invasion, creating a self-sustaining pro-tumorigenic loop (Yilmaz et al., 2023)

Mol Neurobiol 59:24722496 [DOI] [PubMed] [Google Scholar] Beger RD, Schmidt MA, Kaddurah-Daouk R (2020) Current concepts in pharmacometabolomics, biomarker discovery, and precision medicine