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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Keegan A., Jack A.M., Cotter M.A., Cameron N.E

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As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors

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