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95 A more extreme treatment option is kidney transplantation, which does not reduce TMAO production but does increase its clearance

43 Reported adverse reactions in one RTC include headache, facial paresthesia, nausea, biliary colic, vomiting, epigastric pain, and GI disorders, yet they did not differ significantly between placebo and treatment groups

Driven by reaping high profits, -agonists are often illegally fed to animals

Apart from this, it is used for lack of L-carnitine

Although there are some links between TMAO and MAFLD and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in animal models, whether reducing TMAO concentrations could prevent MAFLD remains unclear due to lack of relevant studies