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Prodrugs are inactive compounds designed to be metabolized into active forms, which improves drug properties like solubility and absorption

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However, the use of plasmid-mediated siRNAs has limitations of rapid enzymatic degradation or unwarranted hyper-stimulated immune reaction and the most serious drawback was the random siRNA insertion into chromosomes [123]

Future research should explore whether the anti-inflammatory and mitochondrial mechanisms observed in the KD might serve as adjunctive support in the treatment of Graves disease, particularly during the recovery or remission phases