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Combining these treatments leverages the benefits of both therapies, creating a synergistic effect

Methods/design Study type This study takes the form a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting, with a duration of one year

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Poor oral health People who do not brush their teeth or floss regularly may experience changes in taste, including a metallic taste

EA at CV4 and ST36 can reduce the expression of CRH mRNA in the hypothalamus, downregulate ACTH and CORT levels in plasma, and significantly increase hippocampal serotonin concentration and 5-hydroxytryptamine receptor 1A (5-HT1AR) mRNA and proteins expression, improving adverse emotions in rats (Le et al., 2016)