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Ascorbic Acid and Ascorbyl Glucosamine, the two main forms of Vitamin C, are the best of antioxidants

These data confirm the important role of TREK-1 and TRAAK in CIPN [82, 83]

These findings and interpretations are indirectly supported by a recent report on fatigue in the long COVID-19 syndrome where lower peripheral serotonin was observed in patients than in healthy controls ( Peripheral 5-HT is produced and secreted by the enterochromaffin cells in the gastrointestinal tract where it regulates intestinal mobility

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Future trials should evaluate sequential ferroptosis-immunotherapy regimens may reveal strategies to elicit durable, tumor-specific immune responses and improve glioblastoma outcomes