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Acknowledgments We thank Vilim Simanek, in memoriam, for his guidance on writing this paper

*Correspondence: Maria Paula Macedo, [email protected] This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Suppressed thyroid-stimulating hormone (TSH) levels, along with elevated free T4 and/or T3 and positivity for TSHR autoantibodies (TRAb), are indicative of GD